Distribution of injected I 131 labeled antibody to dog fibrin in tumor-bearing dogs.

Radiodine-labeled antibody to dog fibrin was prepared and injected intravenously into ~8 dogs with spontaneous tumors. The I TM content of tumor tissue was determined 3 days later. Most tumors showed no preferential concentration of I TM. In a few instances preferential 1 in localization was found, and in at least one tumor it was great enough to suggest that, if similar localization occurs in some types of human cancer, highly radioactive antibody of this type might be a useful tool for selective radiation of malignant tumor tissue.